饶恩于

基本介绍

饶恩于，博士，教授。在南开大学获得学士和硕士学位；在中国科学院动物研究所获得博士学位；2011年至2016年间在密歇根大学、明尼苏达大学和路易斯维尔大学进行博士后训练；2016年至2018年在芝加哥大学放射与肿瘤系任助理教授；2018年回国受聘于徐州医科大学。2018年和2019年分别入选江苏特聘教授和江苏特聘医学专家。

研究方向：

1.肿瘤放疗与免疫治疗

2.肿瘤免疫治疗新靶点的探索

论文、专利、项目、获奖等

长期从事肿瘤免疫学研究，在Science Immunology、Leukemia、TheAmerican Journalof pathology等杂志发表论文20余篇。累计影响因子140多，他引1000余次。

1、Wang Y, Zhang X, Hu C, Xie G, Kong S, Yang H, Guo Y, Han Z, Fan Y, Shi X, Wang G*,Rao E*.Lactic acid facilitates the generation of regulatory T cells and promotes cancer progression by activating latent TGF-β1.Int Immunopharmacol. 2026 Jun 24;186:117066.

2、Hou Y, Yang K, Wang L, Wang J, Huang X, Piffkó A, Luo SZ, Yu X,Rao E, Martinez C, Bugno J, Mack M, Vokes EE, Pitroda SP, Chmura SJ, Weichselbaum RR, Liang HL. Radiotherapy Enhances Metastasis Through Immune Suppression by Inducing PD-L1 and MDSC in Distal Sites.Clin Cancer Res. 2024 May 1;30(9):1945-1958

3、Yaru Guo, Jiuzhou Chen, Xiwen Zhang, Miao Fang, Mingna Xu, Longzhen Zhang,Enyu Rao*and Yong Xin*. Recombinant Human Adenovirus-p53 Therapy for the Treatment of Cervical Cancer: A Meta-Analysis.Frontiers in oncology,11:748681，2021(IF 6.2)

4、Enyu Rao, Yuzhu Hou, Xiaona Huang, Liangliang Wang, Jiaai Wang, Wenxin Zheng, Hengjin Yang, Xinshuang Yu, Kaiting Yang, Jason Bugno, Xingchen Ding, Everett Vokes, Yang-Xin Fu, Ralph R. Weichselbaum, Hua L. Liang. All-trans retinoic acid overcomes solid tumor radioresistance by inducing inflammatory macrophages.Science Immunology2021, 6(60)

5、Hou Y, Liang H,Rao E, Zheng W, Huang X, Deng L, Zhang Y, Yu X, Xu M, Mauceri H, Arina A, Weichselbaum RR, Fu YX. Non-canonical NF-κB Antagonizes STING Sensor-Mediated DNA Sensing in Radiotherapy.Immunity.2018 Sep 18;49(3):490-503

6、Zhang Y,Rao E,Zeng J, Hao J, Sun Y, Liu S, Sauter ER, Bernlohr DA, Cleary MP, Suttles J, Li B.Adipose Fatty Acid Binding Protein Promotes Saturated Fatty Acid-Induced Macrophage Cell Death through Enhancing Ceramide Production.J Immunol.2017 Jan 15;198(2):798-807

7、Rao E,Zhang Y, Li Q, Hao J, Egilmez NK, Suttles J, Li B,AMPK-Dependent and Independent Effects of AICAR and Compound C on T-cell responsesOncotarget.2016 Jun 7;7(23):33783-95

8、Zhang Y, Li Q,Rao E, Sun Y, Grossmann ME, Morris RJ, Cleary MP, Li B.Epidermal Fatty Acid binding protein promotes skin inflammation induced by high-fat diet.Immunity.2015 May 19;42(5):953-64

9、Rao E, Singh P, Li Y, Zhang Y, Chi YI, Suttles J, Li B.Targeting epidermal fatty acid binding protein for treatment of experimental autoimmune encephalomyelitis.BMC Immunol.2015 May 12;16:28

10、Rao E, Singh P, Zhai X, Li Y, Zhu G, Zhang Y, Hao J, Chi YI, Brown RE, Cleary MP, Li B.Inhibition of tumor growth by a newly-identified activator for epidermal fatty acid binding protein.Oncotarget. 2015 Apr 10;6(10):7815-27.

11、Rao E, Zhang Y, Zhu G, Hao J, Persson XM, Egilmez NK, Suttles J, Li B.Deficiency of AMPK in CD8+ T cells suppresses their anti-tumor function by inducing protein phosphatase-mediated cell death.Oncotarget.2015 Apr 10; 6(10):7944-58.

12、Zhang Y, Sun Y,Rao E, Yan F, Li Q, Zhang Y, Silverstein KA, Liu S, Sauter E, Cleary MP, Li B.Fatty acid-binding protein E-FABP restricts tumor growth by promoting IFN-β responses in tumor-associated macrophages.Cancer Res.2014 Jun 1;74(11):2986-98

13、Enyu Rao, Chunsun Jiang, Timothy McKeithan, Ming Ji, Javeed Iqbal, George Wright, Louis M. Staudt, Yong Zhao, Wing C. Chan, and Kai Fu.The miRNA-17∼92 cluster mediates chemoresistance and enhances tumor growth in mantle cell lymphoma via PI3K/AKT pathway activation.Leukemia.2012 May;26(5):1064-72

14、Ming Ji,Enyu Rao(co-first author), Himabindu Ramachandrareddy, Yulei Shen, Chunsun Jiang, Yong Zhao, Jianxiu Chen, Yiqiao Hu, Angie Rizzino, Wing C. Chan, Kai Fu, and Timothy W. McKeithan. The miR-17-92 MicroRNA Cluster Is Regulated by Multiple Mechanisms in B-Cell Malignancies.The American Journal of Pathology,2011 Oct;179(4):1645-56