柴大飞，本硕博毕业于苏州大学，医学博士，美国贝勒医学院博士后、Instructor,现为徐州医科大学副教授，硕士生导师，江苏省高校“青蓝工程”中青年学术带头人，主要从事肿瘤抗体、疫苗靶向治疗及其作用机制研究。在此领域获得国家自然科学基金项目2项、江苏省自然科学基金青年项目1项、江苏省教育厅重点研发项目1项、徐州市重点研发计划项目1项的支持。截止目前为止，在J Hematol Oncol、Blood、Mol Cancer、Mol Ther、J Immunother Cancer、Cancer Lett、NPJ Vaccines、Pharmacol Res等专业期刊发表SCI论文60篇。其中以第一作者或通讯作者身份发表32篇。授权国家发明专利6项。获得中华医学科技奖二等奖，江苏医学科技奖一等奖，并指导本科生/研究生获得“大创”国家级项目，“挑战杯”江苏省三等奖，徐州医科大学优秀研究生毕业论文等荣誉称号。目前担任Genes & Diseases杂志副主编以及J Hematol Oncol、Mol Ther、Pharmacol Res、Frontier in immunology等杂志客座编辑或审稿人。
近三年代表论文：
1.Wang J1, Wang Z1, Zhao W, Chen H, Lu B, Shao Y, Zheng Y, Liu S, Wang M, Fang L, Li H, Neeli P, Tian H*, Wang G*,Chai D*. VISTA neutralization by immunization reprograms immunosuppression and augments vaccine efficacy in renal carcinoma.J Immunother Cancer. 2026 May;14(5):e015052.
2.Chai D1, Wang J1, Lim JM, Xie X, Yu X, Zhao D, Maza PAM, Wang Y, Cyril-Remirez D, Young KH, Li Y*. Lipid nanoparticles deliver DNA-encoded biologics and induce potent protective immunity.Mol Cancer. 2025 Jan 13;24(1):12.
3.Chai D, Li Y*. Expanding nucleic acid-encoded medicine.Mol Ther. 2025 Jan;33(1):16-17.
4. Zheng Y1, Wang J1, Zhao G, Zhang Z, Shao Y, Lu B, Zhang Y, Chen R, Sun L, Xie X, Ding J*, Zheng J*,Chai D*. Targeting Siglec-E facilitates tumor vaccine-induced antitumor immunity in renal carcinoma.J Immunother Cancer. 2025 Jan;13(1):e010521.
5. Lu B1, Chai L1, Zhang Z, Zhao G, Shao Y, Zheng Y, Jin X, Zheng J*,Chai D*, Ding J*. Co-immunization with IFI35 enhances the therapeutic effect of an adenovirus vaccine against renal carcinoma.Int J Biol Macromol. 2025 Jan;286:138515.
6.Chai D1, Wang J1, Fan C, Lim JM, Wang X, Neeli P, Yu X, Young KH, Li Y. Remodeling of anti-tumor immunity with antibodies targeting a p53 mutant.J Hematol Oncol.2024 Jun 18;17(1):45.
7.Chai D1, Wang X1, Fan C, Wang J, Lim JM, Yu X, Young KH, Li Y*. Vaccines targeting p53 mutants elicit anti-tumor immunity.Cancer Lett.2024 Dec;611:217421.
8. Zhu F1, Lu Z1, Tang W, Zhao G, Shao Y, Lu B, Ding J, Zheng Y, Fang L, Li H, Wang G, Chen R*, Zheng J*,Chai D*. Adenovirus vaccine targeting kinases induces potent antitumor immunity in solid tumors.J Immunother Cancer. 2024 Aug;12(8):e009869.
9. Jiang N1, Zheng Y1, Ding J, Wang J, Zhu F, Wang M, Sobhani N, Neeli P, Wang G, Li H, Zheng J*,Chai D*. The co-delivery of adenovirus-based immune checkpoint vaccine elicits a potent anti-tumor effect in renal carcinoma.NPJ Vaccines. 2023 Aug;8(1):109.
10.Chai D1, Wang X1, Neeli P, Zhou S, Yu X, Sabapathy K, Li Y*. DNA-delivered monoclonal antibodies targeting the p53 R175H mutant epitope inhibit tumor development in mice.Genes Dis. 2023 Jun;11(4):100994.
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