马波

电子邮箱：boma@xzhmu.edu.cn

马波，教授，博士生导师。本科、硕士毕业于东北师范大学，2010年博士毕业于中国科学院动物研究所膜生物学国家重点实验室。之后进入美国匹兹堡大学医学院，从事博士后研究，2014年晋升为副研究员。2019年入职徐州医科大学，建立类器官芯片与肿瘤转移研究组。2020年入选“江苏特聘教授”（特别资助）、“江苏双创人才”、“江苏省特聘医学专家”， 并作为核心成员获评江苏省卫生创新团队，江苏省“双创团队”。江苏省研究型医院学会肿瘤放疗分会委员，江苏省免疫学会转化分会委员。主持国自然面上项目1项，江苏省高等学校基础科学（自然科学）研究重大项目1项，江苏省研究生教育教学改革课题重大课题1项。先后在国际高水平期刊发表SCI论文28篇，包括以第一、通讯作者在Nature Immunology、Hepatology等期刊发表SCI论文18篇，受邀在Seminars in Cancer Biology (2020, 2021)、Trends in Cancer Biology (2025，ESI高水平、高被引论文)撰写综述文章，他引1600余次。担任Innovation、Exploration等10余种SCI杂志审稿人。细胞治疗药学专业建设负责人，《应用细胞生物学》、《癌症与细胞免疫治疗前沿（留学生）》课程负责人。

Publications：

1.Yining Feng, Fei Chen, Chenglong Mu, Luqi Wang, Yuhan Jiang, Dan Liu, Dameng Li, Chen Liang, Yanhua Zhai, Tao Yang, Alan Wells, Amanda M Clark*, Liang Wei*,Bo Ma*.M1 macrophages enhance breast cancer chemoresistance via JAK-STAT3 signaling.Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease. 2025

2.Yang Tian, Wei Li, Qing Zhai, Ying Yu, Jiaxin Yuan, Yan Ma, Jingjing Yang, Mingyue Li, Wenwen Chang, Wenjing Li, Keke Huang, Chongran Sun, Chen Zeng, Yingdi Sun, Jiabao Gu, Huilin Zhang, Dameng Li, Yanan Yu, Lu Hu, Peng Zhang,Bo Ma, Junnian Zheng, Pan Li, Feng Guo, Yang Sun.Pharmacological Targeting of DHHC9‐Mediated STRN4 Palmitoylation to Suppress YAP‐Driven Cancer Metastasis.Journal of Cellular and Molecular Medicine. 2025, 29 (17), e70815

3.Yuxin Chen, Lulu Han, Ying Cai, Shuxin Huang, Meng Wang, Huizhong Li, Junnian Zheng*,Bo Ma*, Gang Wang*. Gene armoring: A way to enhance CAR-T cell function.Pharmacological research. 2025 Jan 25

4.Chen Liang, Xiao Liu, Jie Yu, Lingyun Shi, Wenchao Wei, Yalu Zhu, Maoping Feng, Tingting Tang, Dameng Li, Tao Yang, Junnian Zheng*,Bo Ma*, Liang Wei*. Hypericin photoactivation induces triple-negative breast cancer cells pyroptosis by targeting the ROS/CALR/Caspase-3/GSDME pathway.Journal of Advanced Research. 2025 Jan 25

5.Kaili Ma, Lin Wang, Wenhui Li, Tingting Tang,Bo Ma*, Liyuan Zhang*, Lianjun Zhang*. Turning cold into hot: emerging strategies to fire up the tumor microenvironment.Trends in Cancer. 2024 Dec 26

6.Tingting Tang, Tao Yang, Huijie Xue, Xiao Liu, Jie Yu, Chen Liang, Dameng Li, Chenxi Xiang, Junnian Zheng*, Liang Wei*,Bo Ma*. Breast cancer stem cell-derived exosomal lnc-PDGFD induces fibroblast-niche formation and promotes lung metastasis.Oncogene.2024 Dec 4:1-17

7.Yuxin Chen, Meng Wang, Shuxin Huang, Lulu Han, Ying Cai, Xiaodi Xu, Shuwen Sun, Zhaokai Chen, Junze Chen, Jiatian Yu, Hongwei Du, Huizhong Li, Junnian Zheng*,Bo Ma*, Gang Wang*.Ectopic expression of NKG7 enhances CAR-T function and improves the therapeutic efficacy in liquid and solid tumors.Pharmacological Research.2024; 210:207506

8.Li D, Zhou X, Xu W, Cai Y, Mu C, Zhao X, Liang C, Yang T, Zhang J*, Wei L*,Ma B*. High-fat diet promotes prostate cancer metastasis via RPS27.Cancer & Metabolism.2024 12 (1), 6

9.Li D, Zhou X, Xu W, Chen Y, Mu C, Zhao X, Yang T, Wang G, Wei L*,Ma B*. Prostate cancer cells synergistically defend against CD8+ T cells by secreting exosomal PD-L1.Cancer Med.2023; 12: 16405-16415.

10.Shi K, Chen F, Li X, Liang C, Sun H, Yang T, Zheng J,Ma B*, Wei L* (2023). Ginsenosides and Ginseng Phenolic Acids Relieve Ionizing Radiation-Induced Pyroptosis and Apoptosis in Intestinal Epithelial Cells.Natural Product Communications. 2023;18(8)

11.Ma B*, Shao H, Jiang X, Wang Z, Wu CC, Whaley D, Wells A*. Akt isoforms differentially provide for chemoresistance in prostate cancer.Cancer Biol Med.2022 19 (5), 635

12.Ma B, Wheeler SE, Clark AM, Whaley DL, Yang M, Wells A. Liver protects metastatic prostate cancer from induced death by activating E-cadherin signaling.Hepatology.2016 Nov;64(5):1725-1742.

13.Liu X^#,Ma B^#, Malik AB, Tang H, Yang T, et al. Bidirectional regulation of neutrophil migration by mitogen-activated protein kinases.Nat Immunol. 2012 Mar 25;13(5):457-64. (^#equal contribution)

14.Ma B, Wells A, Clark AM. The pan-therapeutic resistance of disseminated tumor cells: role of phenotypic plasticity and the metastatic microenvironment.Semin Cancer Biol. 2020; 60, 138-147.

15.Ma B, Wells A, Wei L, Zheng J.Prostate cancer liver metastasis: Dormancy and resistance to therapy.Semin Cancer Biol. 2021; 71,2-9. (IF=11.09)

16.Ma B, Wells A. The mitogen-activated protein (MAP) kinases p38 and extracellular signal-regulated kinase (ERK) are involved in hepatocyte-mediated phenotypic switching in prostate cancer cells.J Biol Chem. 2014 Apr 18;289(16):11153-61.

17.Jiang Y，Wells A*，Sylakowski K，Clark A.M.，Ma B*. Adult Stem Cell Functioning in the Tumor Micro-Environment.Int. J. Mol. Sci.2019, 20, 2566. (* corresponding author)

18.Ma B, Khazali A, Shao H, Jiang Y, Wells A. Expression of E-cadherin and specific CXCR3 isoforms impact each other in prostate cancer.Cell Communication and Signaling2019;17 (1), 164.

19.Ma B, Khazali A, Wells A. CXCR3 in carcinoma progression.Histol Histopathol.2015 Jul;30(7):781-92.

20.Wells A, Clark A, Bradshaw A,Ma B, Edington H. The great escape: How metastases of melanoma, and other carcinomas, avoid elimination.Exp Biol Med. 2019 1535370218820287.

21.Beckwitt CH, Clark AM,Ma B, Whaley D, Oltvai ZN, Wells A. Statins attenuate outgrowth of breast cancer metastases.Br J Cancer.2018 Oct;119(9):1094-1105.

22.Dioufa N, Clark AM,Ma B, Beckwitt CH, Wells A. Bi-directional exosome-driven intercommunication between the hepatic niche and cancer cells.Mol Cancer. 2017 Nov 14;16(1):172.

23.Wells A,Ma B. Friend turned foe: E-cadherin perversely protects micrometastases.Transl Androl Urol. 2017; 6(2):338-340.

24.Clark AM,Ma B, Taylor DL, Griffith L, Wells A. Liver metastases: Microenvironments and ex-vivo models.Exp Biol Med(Maywood). 2016 Sep;241(15):1639-52.

25.Yang M,Ma B, Shao H, Clark AM, Wells A. Macrophage phenotypic subtypes diametrically regulate epithelial-mesenchymal plasticity in breast cancer cells.BMCCancer.2016 Jul 7;16:419.

26.Sun B, Hu X, Liu G,Ma B, Xu Y, Yang T, Shi J, Yang F, Li H, Zhang L, Zhao Y. Phosphatase Wip1 negatively regulates neutrophil migration and inflammation.J Immunol. 2014 Feb 1;192(3):1184-95.

27.Wells A, Grahovac J, Wheeler S,Ma B, Lauffenburger D. Targeting tumor cell motility as a strategy against invasion and metastasis.Trends Pharmacol Sci. 2013 May;34(5):283-9.

28.Tian C, Gao B, Rodriguez Mdel C, Lanz-Mendoza H,Ma B, et al. Gene expression, antiparasitic activity, and functional evolution of the drosomycin family.MolImmunol.2008 Sep;45(15):3909-16. PubMed PMID: 18657321.