方琳

方琳，博士，副教授，硕士生导师，，江苏省“六大人才高峰”。2010年毕业于南京师范大学获细胞生物学博士学位，2014-2015年美国北卡罗来纳教堂山分校莱恩伯格肿瘤中心访问学者。

主要从事靶向性溶瘤腺病毒介导的肿瘤治疗相关研究，主持国家自然基金、江苏省自然基金、省高校重大项目、中国博士后科学基金等项目，发表SCI论文16篇，获徐州市科技进步一等奖。

（一）代表性论文（*通讯作者）

1.N Sun, J Zhang, C Zhang, H Yin, B Zou, Y Geng, W Gao,YZhang, G Wang*, J Zheng*,L Fang*. TRIM56 enhances adenoviral E1A steady state to improve oncolytic adenovirus therapy efficacy.Journal of Virology,2025, 99(7): e0004125.

2.L Fang, X Wang, Y Zhang, C Zhang,X Liu, W Li, Y Zhang, N Sun, J Zheng*, G Wang*.Oncolytic adenovirus armoring with CXCL9 and IL15 shows potent antitumor activity and boosts CAR-T therapy for prostate cancer.Human Gene Therapy, 2025, 36(11-12):884-901.

3.Y Zhu, X Zhang, J, X Wang, Y Liu, J Gao, D Hang,L Fang*, H Zhang*, H Liu*. Engineered oncolytic virus coated with anti-PD-1 and alendronate for ameliorating intratumoral T cell hypofunction.Experimental Hematology & Oncology, 2025, 14(1):16.

4.L Fang, S Yuan, M Wang, C Zhang, X Wang, H Li, J Yang, W Li, N Sun, Q Zhang, Y Zhang, D Chai, H Li, J Zheng*, G Wang*. Recombinant oncolytic adenovirus armed with CCL5, IL-12 and IFN-γ promotes CAR-T infiltration and proliferation in vivo to eradicate local and distal tumors.Cell Death Discovery, 2023, 9(1):328.

5.N Sun, J Zhang, C Zhang, T Xie, Z Zhang, X Wang, W Li, Y Zhang, Z Chen, J Zheng*,L Fang*, G Wang*. Inhibition of human adenovirus replication by TRIM35-mediated degradation of E1A.Journal of Virology, e0070023, 2023.

6.L Fang, W Tian, C Zhang, X Wang, W Li, Q Zhang, Y Zhang, J Zheng*.Oncolytic adenovirus-mediated expression of CCL5 and IL12 facilitates CA9-targeting CAR-T therapy against renal cell carcinoma.Pharmacological Research,189:106701, 2023.

7.C Zhang,L Fang, X Wang,SYuan,WLi, W Tian,JChen,QZhang,YZhang,QZhang*andJZheng*.Oncolytic adenovirus-mediated expression of decorin facilitates CAIX-targeting CAR-T therapy against renal cell carcinoma.Molecular Therapy-Oncolytics, 24:14-25, 2022.

（二）专利

1、苏长青、方琳、苏英晗；一种用于罕少见基因突变的实体瘤治疗的重组溶瘤病毒，2025-05-14,中国，CN202510619667.8

（三）科技奖励

1、2012.12，徐州市科技进步一等奖，新型靶向抗肿瘤溶瘤腺病毒的研制及其作用研究（2/8），2011-1-6-R2

2、2024.04，江苏省高等学校科学技术研究成果奖二等奖，靶向B7H3的全人源免疫细胞治疗技术及应用（3/5）2023-2-54-R3